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Eldepryl may be prescribed as a monotherapy to people with early Parkinson's disease, or as an adjunctive (add-on) treatment in those who are taking levodopa/carbidopa and experiencing reductions in its effectiveness. Eldepryl … Eldepryl is contra-indicated in patients with known hypersensitivity (including severe dizziness or hypotension) to selegiline or any of the excipients listed in section 6.1. Eldepryl is contra-indicated in patients receiving treatment with serotonin-agonists (e.g. sumatriptan, naratriptan, zolmitriptan and rizatriptan). Learn about Eldepryl: What is it used for, what you need to know before taking, important warnings and safety info, how to take, side effects and more… Eldepryl contains the active substance selegiline hydrochloride. Eldepryl is a monoamine oxidase-B inhibitor, and is used in the treatment of Parkinson's disease. 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This medicine works to increase and extend the effects of levodopa, and may help to slow the progress of Parkinson's disease. This medicine is available only with your doctor's prescription. Selegiline is used to help control the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) in people who are taking levodopa and carbidopa combination (Sinemet). Selegiline may help people with Parkinson's disease by decreasing the dose of levodopa/carbidopa needed to control symptoms, stopping the effects … Pharmacological properties Selegiline is a selective mao-b inhibitor that also inhibits dopamine reuptake and the dysamine presynaptic receptor. these effects potentiate dopaminergic function in the brain. 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