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Get the best price on Xifaxan at pharmacies near you with SingleCare. Save up to 80% with our Xifaxan coupons – with or without insurance! Xifaxan (rifaximin) is used to treat traveler's diarrhea and irritable bowel syndrome with diarrhea. It is also used to prevent hepatic encephalopathy, a brain disorder that can occur due to severe liver disease. Xifaxan is a rifamycin which works by killing bacteria that causes infection. The most common form of Xifaxan is a 550mg tablet. Xifaxan costs about $461 for six tablets. Learn how the Xifaxan coupon, Xifaxan savings card, and other tools can help you save. You must activate this coupon before using it by visiting XIFAXAN.com, calling 1-866-XIFAXAN, or texting PAYZERO to 69970. You will receive a link to activate your copay savings card via SMS and opt-in to refill reminders. Message and data rates may apply. Message frequency varies. Text HELP for help, STOP to opt out. 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