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Find patient medical information for Trazodone on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Trazodone is a prescription medication most commonly used to treat depression, but it's also often prescribed off-label to help with sleep problems like insomnia. Trazodone belongs to a class of drugs called serotonin modulators, which help improve mood and promote relaxation. At lower doses, its sedating effects tend to be more noticeable – making it a popular option for people who have … Taking trazodone together with anesthetic medicines (numbing medicines) that are used during surgery, dental treatments, or emergency treatments may cause an increase in CNS depressant effects. Trazodone may cause dry mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. TRAZODONE (TRAZ oh done) treats depression. 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