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Disulfiram, formerly known by the brand name Antabuse, is a medication approved by the U.S. Food and Drug Administration (FDA) that is used in the treatment of alcohol use disorders (AUD). 1 Disulfiram produces unpleasant side effects and sensitivity when mixed with alcohol. It is designed as a deterrent to drinking. 2 Normally, when alcohol enters the body, it is converted into acetaldehyde … Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage. 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